COPD

Inhaler Therapy

• UPLIFT - Tiotropium in Chronic Obstructive Pulmonary Disease - NEJM 2008
• IMPACT - Single Inhaler Triple versus Dual Bronchodilator Therapy in Chronic Obstructive Pulmonary Disease - NEJM 2018
• TRINITY - Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease - Lancet 2016
• TRILOGY - Single inhaler extrafine triple therapy versus long-acting muscarinic antagonist therapy for chronic obstructive pulmonary disease - Lancet 2016
• ETHOS - Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD - NEJM 2020

Exacerbations

• REDUCE - Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease - JAMA 2013
• ALBERT - Azithromycin for Prevention of Exacerbations of COPD - NEJM 2011